Osteosarcoma and PTHrp
PTHrp expression in osteosarcoma tumor tissue is associated with a more guarded prognosis.
Osteosarcoma metastasis after initial treatment
Dogs receiving surgery to remove metastatic pulmonary nodules who met criteria as good candidates lived longer (8 months) than those who did not (1.5 months) after diagnosis of metastasis.
Criteria for surgery included:
less than 3 pulmonary nodules
Disease free > 9 months after amputation
Stage III OSA
Dogs with metastatic osteosarcoma at the time of initial diagnosis lived longest when treated palliatively with radiation and chemotherapy.
surgery: 3 days
NSAIDs alone: 1 month
Surgery and chemotherapy: 3 months
Radiation and chemotherapy: 4 months
Hemangiosarcoma and time to first Chemotherapy
Starting chemotherapy within 3 weeks of splenectomy is important for survival duration in dogs with stage II or lower splenic hemangiosarcoma.
Inhibition of tumor angiogenesis has become a clinical anti-cancer strategy in line with chemotherapy, radiotherapy and surgery, which underscore the critical importance of the angiogenic switch during early tumor development.